Nwapa also is known for her governmental work in reconstruction after the Biafran War. In particular she worked with orphans and refugees who were displaced during the war. Further she worked as a publisher of African literature and promoted women in African society. She was one of the first African women publishers when she founded Tana Press in the 1970s. Nwapa's first book, Efuru, was published in 1966, a pioneering work as an English-language novel by an African woman writer. It was followed by the novels Idu (1967), Never Again (1975), One is Enough (1981) and Women Are Different (1986). She published two collections of stories — This Is Lagos (1971) and Wives at War (1980) — and the volume of poems Cassava Song and Rice Song (1986). She was also the author of several books for children.

Nwapa's career as an educator continued throughout her life and encompassed teaching at colleges and universities internationally, including at the University of Ilorin, New York University, Trinity College[disambiguation needed], University of Minnesota, and University of Michigan, . She said in an interview with Contemporary Authors, "I have been writing for nearly thirty years. My interest has been on both the rural and the urban woman in her quest for survival in a fast-changing world dominated by men." Flora Nwapa died from pneumonia on 16 October 1993 in hospital in Enugu, Nigeria, at the age of 62.