
Chandrasekhar worked on a wide variety of physical problems in his lifetime, contributing to the contemporary understanding of stellar structure, white dwarfs, stellar dynamics, stochastic process, radiative transfer, the quantum theory of the hydrogen anion, hydrodynamic and hydromagnetic stability, turbulence, equilibrium and the stability of ellipsoidal figures of equilibrium, general relativity, mathematical theory of black holes and theory of colliding gravitational waves.[6] At the University of Cambridge, he developed a theoretical model explaining the structure of white dwarf stars that took into account the relativistic variation of mass with the velocities of electrons that comprise their degenerate matter.

Chandrasekhar studied at Presidency College, Madras (now Chennai) and the University of Cambridge. He spent most of his career at the University of Chicago, spending some time in its Yerkes Observatory, and serving as editor of The Astrophysical Journal from 1952 to 1971. He served on the University of Chicago faculty from 1937 until his death in 1995 at the age of 84. Chandrasekhar married Lalitha Doraiswamy in September 1936. He had met her as a fellow student at Presidency College, Madras. Chandrasekhar was the nephew of Sir Chandrasekhara Venkata Raman, who was awarded the Nobel Prize for Physics in 1930. He became a naturalized citizen of the United States in 1953.