In 1995, Lange moved to Los Angeles to star in the first season of Mad TV. His arrest for cocaine possession during the second season led to his departure and subsequent rehabilitation. In 1997, Norm Macdonald chose Lange to co-star in his comedy film Dirty Work (1998), which secured Lange several film and television roles including Macdonald's sitcom, The Norm Show. In 2001, Lange returned to New Jersey and became a member of The Howard Stern Show until December 2009. He pursued various projects during this time; he released two comedy albums, co-wrote, produced, and starred in his feature film, Artie Lange's Beer League (2006), and released his first book, Too Fat to Fish (2008), which entered The New York Times Best Seller list at number one.
In 2011, Lange completed rehabilitation and resumed his career. He returned to stand up and co-hosted The Nick & Artie Show with Nick Di Paolo until Di Paolo's departure in 2013; the show was renamed The Artie Lange Show and lasted until 2014. During this time, Lange released his second book, Crash and Burn (2013). He launched The Artie Quitter Podcast in 2015 and continues to perform stand up and act. His third book is set for release in 2017.