Michelle (Mary Elizabeth Winstead) packs her things and leaves her apartment, angry over a dispute with her partner Ben (Bradley Cooper). While driving away she turns on the radio; it claims that there are numerous blackouts in major cities. Michelle becomes distracted after Ben calls her, and her car crashes and goes off the road from the distraction, flipping upside down. When she awakens, she discovers she is chained to the wall in an unknown location. After reaching her phone only to receive no signal, a man named Howard (John Goodman) enters the room and tells her he saved her life and the world outside is now uninhabitable due to the nuclear or chemical fallout from "an attack."
Skeptical, but trying to be careful, she pretends to accept this reality. Once freed from her chains and able to walk with crutches, she meets Emmet (John Gallagher, Jr.) who believes Howard's story. During dinner, Howard snaps after Michelle flirts with Emmet to get the keys from Howard's belt. When she does, and the situation calms, she smashes a bottle in Howard's face and tries to escape. She makes it to the threshold of the door of the air-locked bunker, only to be surprised by the sight of a car and a woman, whose skin is horribly disfigured and peeling, begging to be let in. Howard yells at her not to let her in. She ultimately does not, and returns to the bunker. Now believing the outside world is uninhabitable, Michelle manages to adapt to her new life in the bunker. Howard confesses to Michelle that he accidentally crashed into her car, and shows her a picture of his daughter, Megan, and explains her mother took her away from him and moved to Chicago.
One night, Howard calls both of them in the living room, playing coy and asking what they are up to, showing them the scissors and duct tape they had been using. He presents to them a barrel containing highly corrosive perchloric acid. When Howard starts getting angry, Emmet lies to Howard and says he had been making a weapon because he wanted Michelle to respect him like how she admires Howard. He apologizes to Howard. Howard accepts his apology, then immediately shoots Emmet in the face, killing him. Some time later, Michelle's suit is complete and Howard comes into Michelle's room, discovering the suit hidden under her bed. Michelle runs out of the chamber and locks Howard inside. Michelle runs into the living room to try and find a weapon when Howard appears behind her. She knocks over the barrel of acid onto the floor, and Howard slips on it, burning him. The acid causes the wire in one of the lamps to short out and cause an electrical fire. Michelle runs back to get the suit and manages to get to the air filtration room via the vent. Outside, she sees birds flying, takes off her mask, and discovers the air is breathable. She then sees a giant alien spaceship hovering over the corn crops. The bunker explodes due to the fire, which attracts the ship. She runs to a car outside the bunker, and the car alarm goes off, attracting an alien that looks like a black crystal-leopard.
She runs into the barn to escape from the alien and manages to get out and runs to Howard's truck. The ship reappears and drags the truck in the air while Michelle finds a lighter, magazine and a bottle of alcohol. Lighting it on fire, she throws it into the mouth of the alien. The alien explodes, and the truck drops to the ground. When Michelle wakes up, she exits the truck and gets into the car. Michelle drives away, knocking over a mailbox that says "10 Cloverfield." She hears a distress call on the radio saying areas north of Baton Rouge have successfully fended off the alien invasion while others to the south need more assistance, and there are survivors in Houston in need of medical care and help from those with combat experience. She stops the car, decides what to do, and turns the car to go to Houston. Thunder and lightning reveal more