
Tlali co-founded and contributed to Staffrider magazine, for which she wrote a regular column, "Soweto Speaking", as well as writing for other South African publications, including the Rand Daily Mail. Tlali's literary activities took her to different parts of the world, including the Netherlands, where she worked for a year, and the USA. In 1978, she participated in an international writing programme at Iowa State University, giving lectures in San Francisco, Atlanta, Washington DC, and New York, and between 1989 and 1990 was a visiting scholar at the Southern African Research Program at Yale University.

Close to the time of her death, she was involved in private business, running the non-governmental organisation" Essential Child Care Foundation" involved in child welfare needs and rights as well. Her recent public outings include the Inspire Africa Benefit Concert in January 2009, where she performed alongside her son Kaka and the MTN Musical Festival, a musical show of old and new-breed musicians in 2009. Her second son, Kaka is also towing the music line. He is a hip hop artiste and producer. One of her earliest albums 'Ever Liked my Person' sold above platinum till date. So popular was one of its hit songs 'Seun Rere', that a number of African countries have sung their own version. The singer intended to spend the day with the less-privileged children as she has always done over the years. Essien-Igbokwe died on 30 June 2011 after a brief illness.