
Sosa performed in venues such as the Lincoln Center in New York City, the Théâtre Mogador in Paris and the Sistine Chapel in Vatican City, as well as sell-out shows in New York's Carnegie Hall and the Roman Colosseum during her final decade of life. Her career spanned four decades and she was the recipient of several Grammy awards and nominations, including a posthumous Latin Grammy award for Best Folk Album. She served as an ambassador for UNICEF.

Her body was placed on display at the National Congress building in Buenos Aires for the public to pay their respects, and President Fernández de Kirchner ordered three days of national mourning. Thousands had queued by the end of the day. She was cremated on October 5. Sosa's obituary in The Daily Telegraph said she was "an unrivalled interpreter of works by her compatriot, the Argentine Atahualpa Yupanqui, and Chile's Violeta Parra". Helen Popper of Reuters reported her death by saying she "fought South America's dictators with her voice and became a giant of contemporary Latin American music". Sosa received three Latin Grammy nominations for her album, in 2009 . She went on to win Best Folk Album about a month after her death.