Dubke is a native of Hamburg, New York and attended Hamburg High School. He is a graduate of Hamilton College. According to Dubke, he has been involved in political affairs since 1988. Several of the organizations that he has worked for operate out of the same office building at 66 Canal Center Plaza, Suite 555, Alexandria, Virginia. Questions about election ethics have been raised based on the organizations' various connections to political campaigns.
Michael Dubke, David Carney, and several business groups helped start Americans for Job Security in 1997. Dubke was the first executive director and then president of Americans for Job Security until April 2008. In 2001, Dubke founded the Republican media services firm Crossroads Media[16]. It was brought it to a level of national prominence during the 2008 presidential campaign. The company provides services for American Crossroads, a super PAC founded by Karl Rove. While at Crossroads Media, Dubke worked on the campaign of New York congressman Chris Collins.