
Munoz is the oldest of nine children in a Mexican-American family living in California, and was the first in his family to graduate from college. Munoz earned a BS in business from the University of Southern California and an MBA from Pepperdine University. While at USC, he met his wife Cathy. They have four children, Jessica, Kellie, Kevin, and his youngest son, Jack. Munoz previously served as President and Chief Operating Officer of CSX Corporation, a company he joined in 2003.

Munoz suffered a heart attack on October 15, 2015, just a month after becoming the CEO of United Airlines. His condition was not immediately known. United Airlines said Munoz was hospitalized in Chicago and said further details would be released at a later time. On January 6, 2016, United Airlines announced that Munoz had undergone a heart transplant that day and was in recovery. He returned to work on March 7, 2016.

This is an upsetting event to all of us here at United. I apologize for having to re-accommodate these customers. Our team is moving with a sense of urgency to work with the authorities and conduct our own detailed review of what happened. We are also reaching out to this passenger to talk directly to him and further address and resolve this situation.
The response was criticized widely by public relations experts such as Rupert Younger, director of the Oxford University Centre for Corporate Reputation, who called the response "a major disappointment." [undue weight? – discuss]