Ifill was born in New York City, the fifth child of African Methodist Episcopal (AME) minister (Oliver) Urcille Ifill, Sr., a Panamanian of Barbadian descent who emigrated from Panama, and Eleanor Ifill, who was from Barbados. Her father's ministry required the family to live in several cities in New England and on the Eastern Seaboard during her youth, where he pastored AME churches. In her childhood, she lived in Pennsylvania and Massachusetts church parsonages and in federally subsidized housing in Buffalo and New York City. She graduated in 1977 with a Bachelor of Arts in communications from Simmons College, in Boston, Massachusetts.
Ifill died of endometrial cancer on November 14, 2016, at age 61.[25] Sara Just, PBS NewsHour executive producer and senior vice president of public television station WETA-TV, praised Ifill as "a journalist’s journalist." President Barack Obama extended his condolences to the Ifill family, stating that he "always appreciated [her] reporting even when [he] was at the receiving end of one of her tough interviews." The Republican Speaker of the House, Paul Ryan, expressed his sadness and described her as "an incredibly talented and respected journalist."